Hormonal regulation of male germ cell development
نویسندگان
چکیده
منابع مشابه
Regulation of Male Germ Cell Apoptosis
Testicular tissue is extremely sensitive to external stress such as cancer treatments, which induce inappropriate germ cell apoptosis leading to defects in reproductive health (1, 2). For postpubertal men, cryopreservation of sperm or testicular tissue is a proven method for preserving fertility against the effects of these treatments (3). Unfortunately, no such method exists for prepubertal bo...
متن کاملMale germ cell apoptosis: regulation and biology.
Cellular apoptosis appears to be a constant feature in the adult testis and during early development. This is essential because mammalian spermatogenesis is a complex process that requires precise homeostasis of different cell types. This review discusses the latest information available on male germ cell apoptosis induced by hormones, toxins and temperature in the context of the type of apopto...
متن کاملDynamics of male canine germ cell development
Primordial germ cells (PGCs) are precursors of gametes that can generate new individuals throughout life in both males and females. Additionally, PGCs have been shown to differentiate into embryonic germ cells (EGCs) after in vitro culture. Most studies investigating germinative cells have been performed in rodents and humans but not dogs (Canis lupus familiaris). Here, we elucidated the dynami...
متن کاملMale germ cell development in humans.
BACKGROUND Germ cells are unique cells that possess the ability to transmit genetic information between generations. Detailed knowledge about the molecular and cellular mechanisms determining the fate of human male germ cells still remains sparse. This is partially due to ethical issues limiting the access to research material. Therefore, the mechanisms of proliferation, differentiation and apo...
متن کاملHormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive.
A better understanding of the hormonal regulation of spermatogenesis may provide new avenues for management of human infertility, and development of safe and reversible contraceptives. Although much basic work must be conducted in lower mammals, primarily rodents, concepts must, at some stage, be tested for their relevance to humans. In this review, we will draw together existing data in humans...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2010
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe-10-0025